Annette Bening
- In Love
2027
- The Bride!
2026 Dr. Euphronious
- Lucky
2026 Priscilla Masterson
- Dutton Ranch
2026 Beulah Jackson
- Behind the Lines
2024 Narrator (voice)
- Poolman
2024 Diane Espilnade
- Apples Never Fall
2024 Executive Producer
- NYAD
2023 Diana Nyad
- Death on the Nile
2022 Euphemia Bouc
- Jerry & Marge Go Large
2022 Marge Selbee
- Georgetown
2019 Amanda Brecht
- Hope Gap
2019 Grace
- Captain Marvel
2019 Supreme Intelligence / Dr. Wendy Lawson
- The Report
2019 Dianne Feinstein
- The Investigation: A Search for the Truth in Ten Acts
2019 Narrator (voice)
- The Seagull
2018 Irina Arkadina
- Life Itself
2018 Dr. Cait Morris
- Film Stars Don't Die in Liverpool
2017 Gloria Grahame
- Rules Don't Apply
2016 Lucy Mabrey
- 20th Century Women
2016 Dorothea
- Danny Collins
2015 Mary Sinclair
- The Search
2014 Helen
- Girl Most Likely
2013 Zelda
- The Face of Love
2013 Nikki Lostorm
- Ruby Sparks
2012 Gertrude
- Ginger & Rosa
2012 Bella
- The Kids Are All Right
2010 Nic
- I'm Still Here
2010 Thanks
- Mother and Child
2009 Karen
- The Women
2008 Sylvie Fowler
- 14 Women
2007 Narrator (voice)
- Running with Scissors
2006 Deirdre Burroughs
- The Best of The Tony Awards: The Plays
2006 Holly Dancer (segment "Coastal Disturbances")
- Mrs. Harris
2005 Jean Harris
- Being Julia
2004 Julia Lambert
- Open Range
2003 Sue Barlow
- Liberty's Kids
2002 Abigail Adams (voice)
- What Planet Are You From?
2000 Susan Anderson
- American Beauty
1999 Carolyn Burnham
- In Dreams
1999 Claire Cooper
- The Sopranos
1999 Annette Bening
- The Siege
1998 Elise Kraft / Sharon Bridger
- Mars Attacks!
1996 Barbara Land
- Richard III
1995 Queen Elizabeth
- The American President
1995 Sydney Ellen Wade
- Love Affair
1994 Terry McKay
- Bugsy
1991 Virginia Hill
- Regarding Henry
1991 Sarah Turner
- Guilty by Suspicion
1991 Ruth Merrill
- Postcards from the Edge
1990 Evelyn Ames
- The Grifters
1990 Myra Langtry
- Valmont
1989 Merteuil
- The Great Outdoors
1988 Kate Craig
- Hostage
1988 Jill
- Wiseguy
1987 Karen Leland / Maloy
- Manhunt for Claude Dallas
1986 Ann Tillman
- Miami Vice
1984 Vicky
- Turn of Mind
Dr. Jennifer White
- 42.6 Years
Ruthie
