Catherine O'Hara
- Beetlejuice Beetlejuice
2024 Delia
- The Wild Robot
2024 Pinktail (voice)
- Argylle
2024 Ruth
- Elemental
2023 Brook (voice)
- Pain Hustlers
2023 Jackie
- Back Home Again
2021 Mayor Owl (voice)
- Extinct
2021 Alma (voice)
- The Last Kids on Earth: Happy Apocalypse to You
2021 Skaelka (voice)
- The Addams Family
2019 Grandma Frump (voice)
- A.C.O.D.
2013 Melissa
- The Right Kind of Wrong
2013 Tess
- Frankenweenie
2012 Mrs. Frankenstein / Weird Girl / Gym Teacher (voice)
- Temple Grandin
2010 Aunt Ann
- Killers
2010 Mrs. Kornfeldt
- Where the Wild Things Are
2009 Judith (voice)
- Away We Go
2009 Gloria Farlander
- Good Behavior
2008 Jackie West
- Brother Bear 2
2006 Kata (voice)
- Over the Hedge
2006 Penny (voice)
- Penelope
2006 Jessica Wilhern
- Monster House
2006 Mom (voice)
- For Your Consideration
2006 Marilyn Hack
- Game 6
2006 Lillian Rogan
- Barbie in the 12 Dancing Princesses
2006 Duchess Rowena (voice)
- Chicken Little
2005 Tina - Alien Mom (voice)
- Wild About Books
2005
- Surviving Christmas
2004 Christine Valco
- Lemony Snicket's A Series of Unfortunate Events
2004 Justice Strauss
- The Wool Cap
2004 Gloria
- Can't Buy Me Lunch: Another Look at The Rutles
2003 Astro Glide
- A Mighty Wind
2003 Mickey Crabbe
- Orange County
2002 Cindy Beugler
- Speaking of Sex
2001 Connie Barker
- Best in Show
2000 Cookie Fleck
- Edwurd Fudwupper Fibbed Big
2000 Lorna Mae Loon (voice)
- Bartok the Magnificent
1999 Ludmilla (voice)
- Late Last Night
1999 Dr. Fontes
- The Life Before This
1999 Sheena
- Home Fries
1998 Beatrice Lever
- Waiting for Guffman
1997 Sheila Albertson
- Hope
1997 Muriel Macswain
- Pippi Longstocking
1997 Mrs. Prysselius (voice)
- The Last of the High Kings
1996 Cathleen
- Tall Tale: The Unbelievable Adventure
1995 Calamity Jane
- Wyatt Earp
1994 Allie Earp
- The Paper
1994 Susan
- A Simple Twist of Fate
1994 April Simon
- The Nightmare Before Christmas
1993 Sally / Shock (voice)
- Home Alone 2: Lost in New York
1992 Kate
- There Goes the Neighborhood
1992 Jessie Lodge
- Rabbit Ears - Finn McCoul
1991 Narrator (voice)
- Home Alone
1990 Kate
- Little Vegas
1990 Lexie
- Dick Tracy
1990 Texie Garcia
- Betsy's Wedding
1990 Gloria Henner
- I, Martin Short, Goes Hollywood
1989 Nancy Mae
- Andrea Martin... Together Again
1989 Writer
- Beetlejuice
1988 Delia
- The Best of SCTV
1988 Writer
- Heartburn
1986 Betty
- Really Weird Tales
1986 Writer
- The Incredible Time-Travels of Henry Osgood
1986 Marie Antoinette
- After Hours
1985 Gail
- PMS - Premenstrual Syndrome
1985 Writer
- The Last Polka
1985 Lemon Twin
- Rock & Rule
1983 Aunt Edith (voice)
- Rome, Italian Style
1982 Ursula Schneider
- From Cleveland
1980 Writer
- Easter Fever
1980 Scarlett O'Hare (voice)
- Double Negative
1980 Judith
- Nothing Personal
1980 Audrey
- Intergalactic Thanksgiving, or Please Don't Eat the Planet
1979 Ma Spademinder (voice)
- Witch's Night Out
1978 Malicious (voice)
- Twilight Park
Queen Henrietta
