David Hyde Pierce
- Mouse
2026 Mr. Murdaugh
- Hold
2025 Executive Producer
- The Exorcism
2024 Father Conor
- Visiting Birdie
2024 Executive Producer
- Facing the Wind
2024 Executive Producer
- Sky Blossom
2020 Executive Producer
- The Lavender Scare
2019 Dr. Franklin E. Kameny (voice)
- Sharon Isbin: Troubadour
2014 David Hyde Pierce Self - interviewee
- Vanya and Sonia and Masha and Spike
2012 Vanya
- The Perfect Host
2010 Warwick Wilson
- Sondheim! The Birthday Concert
2010 Writer
- Forever Plaid
2009 The Narrator
- Stingray Sam
2009 Narrator
- The Amazing Screw-On Head
2006 Emperor Zombie (voice)
- Frasier: Analyzing the Laughter
2004 Niles Crane
- Hellboy
2004 Abe Sapien (voice) (uncredited)
- Down with Love
2003 Peter MacMannus
- Treasure Planet
2002 Doctor Doppler (voice)
- Full Frontal
2002 Carl
- Laud Weiner
2002 Laud Weiner
- Wet Hot American Summer
2001 Henry
- Chain of Fools
2001 Mr. Kerner
- Osmosis Jones
2001 Drix (voice)
- On the Edge
2001 Barney (segment "Happy Birthday")
- The Tangerine Bear: Home in Time for Christmas!
2000 Bird (voice)
- Isn't She Great
2000 Michael Hastings
- The Mating Habits of the Earthbound Human
1999 The Narrator
- Jackie's Back!
1999 Perry (The Deaf Rehearsal Pianist)
- A Bug's Life
1998 Slim (voice)
- Star Trek: 30 Years and Beyond
1996 Niles Crane
- Nixon
1995 John Dean
- Wolf
1994 Roy McCallister
- Sleepless in Seattle
1993 Dennis Reed
- Addams Family Values
1993 Delivery Room Doctor
- The Fisher King
1991 Lou Rosen
- Little Man Tate
1991 Garth Emmerick
- Vampire's Kiss
1989 Theater Guy
- Crossing Delancey
1988 Mark
- The Appointments of Dennis Jennings
1988 Businessman
- Rocket Gibraltar
1988 Monsieur Henri
- Bright Lights, Big City
1988 Bartender at Fashion Show
- Moving Violations
1985 Immigration Officer
- Vivien & the Florist
John Gielgud
