Dianne Wiest
- Closing Night
2026 Diane
- Practical Magic 2
2026 Jet
- Apartment 7A
2024 Minnie Castevet
- Scene Partners
2023 Meryl Kowalski
- My Father's Dragon
2022 Iris the Rhinoceros (voice)
- I Care a Lot
2021 Jennifer Peterson
- Let Them All Talk
2020 Susan
- The Mule
2018 Mary
- Five Nights in Maine
2016 Lucinda
- Sisters
2015 Deana Ellis
- Rasheeda Speaking
2015 Ileen
- The Humbling
2014 Carol
- The Odd Life of Timothy Green
2012 Ms. Bernice Crudstaff
- Darling Companion
2012 Penny
- The Big Year
2011 Brenda Harris
- Rabbit Hole
2010 Nat
- Rage
2009 Miss Roth
- Synecdoche, New York
2008 Ellen Bascomb / Millicent Weems
- Passengers
2008 Toni
- Dan in Real Life
2007 Nana
- Dedication
2007 Carol
- A Guide to Recognizing Your Saints
2006 Dito's Mother
- Robots
2005 Mrs. Copperbottom (voice)
- Category 6: Day of Destruction
2004 Shirley Abbott
- The Blackwater Lightship
2004 Lily
- Thank You, Doctor Rey
2003 Elisabeth Beaumont
- I Am Sam
2001 Annie Cassell
- Not Afraid, Not Afraid
2001 Paula
- The Simple Life of Noah Dearborn
1999 Sarah McClellan
- The Horse Whisperer
1998 Diane Booker
- Practical Magic
1998 Aunt Jet
- Drunks
1997 Rachel
- The Birdcage
1996 Louise Keeley
- The Associate
1996 Sally Dugan
- Bullets Over Broadway
1994 Helen Sinclair
- Cops & Robbersons
1994 Helen Robberson
- The Scout
1994 Doctor H. Aaron
- Little Man Tate
1991 Jane Grierson
- Edward Scissorhands
1990 Peg
- Parenthood
1989 Helen Buckman Lampkin Bowman
- Cookie
1989 Lenore
- Bright Lights, Big City
1988 Mother
- The Lost Boys
1987 Lucy
- September
1987 Stephanie
- Radio Days
1987 Aunt Bea
- Hannah and Her Sisters
1986 Holly
- The Purple Rose of Cairo
1985 Emma
- Footloose
1984 Vi Moore
- Falling in Love
1984 Isabelle
- The Face of Rage
1983 Rebecca Hammil
- Independence Day
1983 Nancy Morgan
- I'm Dancing as Fast as I Can
1982 Julie Addison
- It's My Turn
1980 Gail
- Out of Our Fathers' House
1978 Elizabeth Gertrude Stern
- Zalmen, or The Madness of God
1975 Nina
- This Old Love of Mine
Margo Bannon
