- The Bend in the River
2025 Executive Producer
- Wolfs
2024 Pam (voice)
- Women Talking
2022 Producer
- The French Dispatch of the Liberty, Kansas Evening Sun
2021 Lucinda Krementz
- Nomadland
2021 Producer
- The Tragedy of Macbeth
2021 Producer
- The Oedipus Project
2020 Jocosta
- Isle of Dogs
2018 Interpreter Nelson (voice)
- Three Billboards Outside Ebbing, Missouri
2017 Mildred
- Hail, Caesar!
2016 C. C. Calhoun
- The Good Dinosaur
2015 Momma (voice)
- Habitat Eart
2015 Narrator
- Every Secret Thing
2014 Producer
- Madagascar 3: Europe's Most Wanted
2012 Chantel DuBois (voice)
- Promised Land
2012 Sue Thomason
- Moonrise Kingdom
2012 Mrs. Bishop
- Transformers: Dark of the Moon
2011 Mearing
- This Must Be the Place
2011 Jane
- The Botany of Desire
2009 Narrator (voice)
- Burn After Reading
2008 Linda Litzke
- Miss Pettigrew Lives for a Day
2008 Guinevere Pettigrew
- Friends with Money
2006 Jane
- Æon Flux
2005 Handler
- North Country
2005 Glory
- Something's Gotta Give
2003 Zoe
- Laurel Canyon
2003 Jane
- City by the Sea
2002 Michelle
- Upheaval
2002 Anne
- The Man Who Wasn't There
2001 Doris Crane
- The Grey Zone
2001 Thanks
- Almost Famous
2000 Elaine Miller
- Wonder Boys
2000 Sara Gaskell
- Edwurd Fudwupper Fibbed Big
2000 The Adult Fannie (voice)
- Madeline
1998 Miss Clavel
- Talk of Angels
1998 Conlon
- Johnny Skidmarks
1998 Alice
- Paradise Road
1997 Dr. Verstak
- Fargo
1996 Marge Gunderson
- Primal Fear
1996 Molly
- Lone Star
1996 Bunny
- Palookaville
1996 June
- Hidden in America
1996 Gus
- Beyond Rangoon
1995 Andy Bowman
- The Good Old Boys
1995 Eve Calloway
- Bleeding Hearts
1995 Woman on TV (archive footage)
- Talking With
1995 Caro (segment "Handler")
- Short Cuts
1993 Betty Weathers
- Crazy in Love
1992 Clare
- Passed Away
1992 Nora Scanlan
- The Butcher's Wife
1991 Grace
- Barton Fink
1991 Stage Actress (voice) (uncredited)
- Darkman
1990 Julie Hastings
- Hidden Agenda
1990 Ingrid Jessner
- Chattahoochee
1990 Mae Foley
- Miller's Crossing
1990 Mayor's Secretary (uncredited)
- Mississippi Burning
1988 Mrs. Pell
- Raising Arizona
1987 Dot
- Vengeance: The Story of Tony Cimo
1986 Brigette
- Blood Simple
1985 Abby
- Crimewave
1985 Nun
- Scandal Sheet
1985
- Jack of Spades
Producer
