Jane Kaczmarek
- The Boroughs
2026 Lilly
- And Now I Lay Me Down
2024 Celia Dalvi
- The Changeling
2023 Cal
- 2 Timers
2021 Diva
- Killing Eleanor
2020 Martina Grillo
- mixed-ish
2019 Eleanor
- Carol's Second Act
2019 Phyllis
- 6 Balloons
2018 Gloria
- CHiPs
2017 Captain Jane Lindel
- Long Day's Journey Into Night
2017 Mary Cavan Tyrone
- Wolves at the Door
2016 Mary
- This Is Us
2016 Mrs. Philips
- The Boat Builder
2015 Katherine
- Salem Rogers
2015 Dana
- Big Time in Hollywood, Fl
2015 Dr. Linda Moore
- Us & Them
2014 Pam
- Penn Zero: Part-Time Hero
2014 Coach Jackie (voice)
- Playing House
2014 Gwen Crawford
- Lost on Purpose
2013 Ms. Liz
- Ruth & Erica
2012 Brenda
- Wilfred
2011 Beth
- Whitney
2011 Patti Morris
- Jake and the Never Land Pirates
2011 Red Jessica (voice)
- Reviving Ophelia
2010 Marie
- The Middle
2009 Sandy Armwood
- Raising the Bar
2008 Judge Trudy Kessler
- The Big Bang Theory
2007 Dr. Gallow
- Help Me Help You
2006 Anne Hoffman
- Wellstone!
2004 Narrator
- Higglytown Heroes
2004 Astronaut Hero (voice)
- Tracey Ullman in the Trailer Tales
2003 Herself
- Jenifer
2001 Valerie Estess
- Malcolm in the Middle
2000 Lois
- Law & Order: Special Victims Unit
1999 Pam James
- Pleasantville
1998 David's Mom
- Felicity
1998 Carol Anderson
- The Practice
1997 Pamela Boyd
- The Chamber
1996 Dr. Anne Biddows
- Wildly Available
1996 Rita Goodman
- Apollo 11: First Steps on the Moon
1996 Jan Armstrong
- Educating Mom
1996 Nancy Gallagher
- Cybill
1995 Holly
- Without Warning
1994 Dr. Caroline Jaffe
- Boys Will Be Boys
1994 Mary Reed
- Party of Five
1994 Helene Thompson
- Monty
1994
- Touched by an Angel
1994 Bonnie Bell
- Frasier
1993 Maureen Cutler
- Big Wave Dave's
1993 Karen Fisher
- Picket Fences
1992 Janice Neiman
- Equal Justice
1990 Linda Bauer
- Law & Order
1990 Janet Rudman
- Spooner
1989 Gail Archer
- All's Fair
1989 Linda
- The Simpsons
1989 Constance Harm (voice)
- D.O.A.
1988 Gail Cornell
- Vice Versa
1988 Robyn
- The Three Kings
1987 Dr. Paula Bolet
- I'll Take Manhattan
1987 Nina Stern
- The Christmas Gift
1986 Susan
- The Right of the People
1986 Alicia
- L.A. Law
1986 Karen Gershon-Woo
- The Heavenly Kid
1985 Emily
- Door to Door
1985 Katharine Holloway
- Hometown
1985
- Falling in Love
1984 Ann Raftis
- Something About Amelia
1984 Mrs. Hall
- Flight 90: Disaster on the Potomac
1984 Donna Olian
- Crazy like a Fox
1984 Julie Floyd
- Uncommon Valor
1983 Mrs. Wilkes
- Right of Way
1983 TV Reporter
- The Last Leaf
1983 Joanna Brady
- Scarecrow and Mrs. King
1983 Penelope 'Penny' Squire / Princess Salana Sharese Khan
- For Lovers Only
1982 Margie Spoleto
- St. Elsewhere
1982 Sandy Burns
- Remington Steele
1982 Barbara Troy Dannon
- American Playhouse
1982 Susan Glaspell
