Jenifer Lewis
- GOAT
2026 Flo Everson (voice)
- A Different World
2026 President Davenport
- Ado
2025 Ms. Hopkins
- Haunted Hotel
2025 Additional Voices (voice)
- Spellbound
2024 Nazara (voice)
- This Is Me…Now
2024 Gemini
- The Fairly OddParents: A New Wish
2024 Mother Nature (voice)
- Night Court
2023 Erika
- Not Dead Yet
2023 Donna
- History of the World: Part II
2023 Grandma
- I Love That for You
2022 Patricia Cochran
- Cars on the Road
2022 Flo (voice)
- So Help Me Todd
2022 Jacqueline Burton
- Finding Kendrick Johnson
2021 Narrator (voice)
- Rugrats
2021 Ms. Marjorie / Narrator (voice)
- The Upshaws
2021 Dr. Pearl Edmunds
- Monsters at Work
2021 Grandma Tuskmon (voice)
- The Ghost and Molly McGee
2021 Patty (voice)
- Mickey Mouse Funhouse
2021 Wheezelene (voice)
- And Just Like That…
2021 Lucille Highwater
- Dolly Parton's Christmas on the Square
2020 Margeline
- Star Trek: Lower Decks
2020 Bartender (voice)
- The Addams Family
2019 Great Auntie Sloom (Voice)
- Amphibia
2019 Mama Hasselback (voice)
- Forbidden
2018
- grown-ish
2018 Ruby Johnson
- Cars 3
2017 Flo (voice)
- Big Hero 6 The Series
2017 Professor Granville (voice)
- The Wedding Ringer
2015 Doris Jenkins
- Secrets of the Magic City
2015 Aunt Valerie
- Think Like a Man Too
2014 Loretta
- The Radiator Springs 500½
2014 Flo (voice)
- black-ish
2014 Ruby Johnson
- Baggage Claim
2013 Catherine Moore
- Hiccups
2013 Flo (voice)
- Teen Titans Go!
2013 Microwavabelle (voice)
- LaQuifa is Halleloosin' It!
2013 Thanks
- Think Like a Man
2012 Loretta Hanover
- Zambezia
2012 Gogo (voice)
- Jenifer Lewis and Shangela
2012 Producer
- When Harry Met Sally 2 with Billy Crystal & Helen Mirren
2011 Retirement Home Waitress (uncredited)
- Cars 2
2011 Flo (voice)
- Five
2011 Maggie
- The Playboy Club
2011 Pearl
- Hereafter
2010 Candace
- Young Justice
2010 Olympia Savage (voice)
- The Princess and the Frog
2009 Mama Odie (voice)
- Not Easily Broken
2009 Mary 'Mama' Clark
- Prop 8: The Musical
2008 Riffing Prop 8'er
- Meet the Browns
2008 Vera
- Who's Your Caddy?
2007 C-Note's Mom
- Redrum
2007 Therapist
- Cars
2006 Flo (voice)
- Dirty Laundry
2006 Aunt Lettuce
- Madea's Family Reunion
2006 Milay Jenay Lori
- Geared-Up
2006
- Shark
2006 Ellie Broussard
- Day Break
2006 Elizabeth Hopper
- American Dad!
2005 Lessie (voice)
- The Boondocks
2005 Boss Willona (voice)
- The Cookout
2004 Lady Em
- Nora's Hair Salon
2004 Nora
- Shark Tale
2004 Motown Turtle (voice)
- Boston Legal
2004 Judge Isabel Fisher
- That's So Raven
2003 Vivian
- Juwanna Mann
2002 Aunt Ruby
- Antwone Fisher
2002 Aunt Mary Williams (uncredited)
- Family Affair
2002 Mrs. Summers
- The Brothers
2001 Louise Smith
- Dancing in September
2001 Judge Warner
- Partners
2000 Detective Lancy
- Little Richard
2000 Muh Penniman
- Cast Away
2000 Becca Twig
- Girlfriends
2000 Veretta Childs
- Bette
2000
- Strong Medicine
2000 Lana Hawkins
- Mystery Men
1999 Lucille
- Jackie's Back!
1999 Co-Producer
- Blast from the Past
1999 Dr. Aron
- Grown Ups
1999 Kathy
- The PJs
1999 Bebe Ho (voice)
- The Mighty
1998 Mrs. Addison
- An Unexpected Life
1998 Camille
- Rituals
1998 Carmen
- The Temptations
1998 Mama Rose
- The Preacher's Wife
1996 Margueritte Coleman
- Girl 6
1996 Boss #1 - Lil
- The Jamie Foxx Show
1996 Josie
- Moesha
1996 Mrs. Biggs
- Promised Land
1996 Queenie
- The Daily Show
1996
- Panther
1995 Rita
- Deadline for Murder: From the Files of Edna Buchanan
1995 Denice Cooper
- Dead Presidents
1995 Mrs. Curtis
- The Parent 'Hood
1995
- Courthouse
1995 Rosetta Reide
- Happily Ever After: Fairy Tales for Every Child
1995 Female Black Widow Spider (voice)
- Deconstructing Sarah
1994 Betty
- Shake, Rattle and Rock!
1994 Amanda
- Corrina, Corrina
1994 Jevina
- Renaissance Man
1994 Mrs. Coleman
- Friends
1994 Paula
- Touched by an Angel
1994 Queenie
- Rebel Highway
1994 Amanda Baldwin Cooper
- Sister Act 2: Back in the Habit
1993 Vegas Backup Singer #1
- Undercover Blues
1993 Cab Driver
- What's Love Got to Do with It
1993 Zelma Bullock
- Poetic Justice
1993 Annie
- The Meteor Man
1993 Mrs. Williams
- Living Single
1993
- Lois & Clark: The New Adventures of Superman
1993 Mystique
- Sister Act
1992 Michelle
- Frozen Assets
1992 Jomisha
- Hangin' with Mr. Cooper
1992 Georgia Rodman
- Sunday in Paris
1991 Taylor Chase
- Roc
1991 Charlaine
- The Fresh Prince of Bel-Air
1990 Aunt Helen
- In Living Color
1990
- Dream On
1990 Carolyn
- Beaches
1988 Diva
- A Different World
1987 Susan Clayton
