Jennifer Jason Leigh
- Crime 101
2026 Angie
- Confession
2026
- Night Always Comes
2025 Doreen
- Poolman
2024 Susan Kerkovish
- Sharp Stick
2022 Marilyn
- The Woman in the Window
2021 Jane Russell 2
- Awake
2021 Dr. Murphy
- Possessor
2020 Girder
- Sid & Judy
2019 Judy Garland (voice)
- Annihilation
2018 Dr Ventress
- White Boy Rick
2018 Alex Snyder
- Amityville: The Awakening
2017 Joan Walker
- LBJ
2017 Lady Bird Johnson
- Good Time
2017 Corey Ellman
- Morgan
2016 Dr. Kathy Grieff
- Welcome to Me
2015 Deb Moseley
- The Hateful Eight
2015 Daisy Domergue
- Alex of Venice
2015 Maureen
- Anomalisa
2015 Lisa Hesselman (voice)
- Hateship Loveship
2014 Chloe
- Jake Squared
2014 Sheryl
- Me
2014 Kelly
- Open
2014 Holly
- Kill Your Darlings
2013 Naomi Ginsberg
- The Spectacular Now
2013 Sara Keely
- The Moment
2013 Lee
- Greenberg
2010 Story
- Synecdoche, New York
2008 Maria
- Margot at the Wedding
2007 Pauline
- The Jacket
2005 Dr. Beth Lorenson
- Rag Tale
2005 Mary Josephine 'MJ' Morton
- Palindromes
2005 'Mark' Aviva
- Easter Sunday
2005 Mother
- The Machinist
2004 Stevie
- Childstar
2004 Suzanne
- In the Cut
2003 Pauline
- Road to Perdition
2002 Annie Sullivan
- Crossed Over
2002 Karla Faye Tucker
- Hey Arnold! The Movie
2002 Bridget (voice)
- The Anniversary Party
2001 Director
- The Man Who Wasn't There
2001 Thanks
- The Quickie
2001 Lisa
- The King Is Alive
2000 Gina
- Skipped Parts
2000 Co-Producer
- O Brother, Where Art Thou?
2000 Thanks
- eXistenZ
1999 Allegra Geller
- Thanks of a Grateful Nation
1998 Teri Small
- The Love Letter
1998 Lizzie Whitcomb
- Washington Square
1997 Catherine Sloper
- A Thousand Acres
1997 Caroline Cook
- Cinema Cinema
1997 Herself
- Kansas City
1996 Blondie O'Hara
- Bastard Out of Carolina
1996 Anney Boatwright
- Dolores Claiborne
1995 Selena St. George
- Georgia
1995 Producer
- Mrs. Parker and the Vicious Circle
1994 Dorothy Parker
- The Hudsucker Proxy
1994 Amy Archer
- Short Cuts
1993 Lois Kaiser
- Single White Female
1992 Hedra 'Hedy' Carlson
- The Prom
1992 Lana
- Backdraft
1991 Jennifer Vaitkus
- Rush
1991 Kristen Cates
- Crooked Hearts
1991 Marriet Hoffman
- Miami Blues
1990 Susie Waggoner
- Buried Alive
1990 Joanna Goodman
- Partners in Life
1990 Blossom
- Last Exit to Brooklyn
1989 Tralala
- The Big Picture
1989 Lydia Johnson
- Heart of Midnight
1988 Carol
- Under Cover
1987 Tanille Laroux
- Sister, Sister
1987 Lucy Bonnard
- The Hitcher
1986 Nash
- The Men's Club
1986 Teensy
- Picnic
1986 Madge Owens
- Flesh + Blood
1985 Agnes
- Grandview, U.S.A.
1984 Candy Webster
- Easy Money
1983 Allison Capuletti
- Girls of the White Orchid
1983 Carol Heath
- Have You Ever Been Ashamed of Your Parents?
1983 Andrea Fairchild
- Wrong Is Right
1982 Young Girl
- Fast Times at Ridgemont High
1982 Stacy Hamilton
- The First Time
1982 Bonnie Dillon
- Eyes of a Stranger
1981 Tracy Harris
- The Killing of Randy Webster
1981 Amy Wheeler
- The Best Little Girl in the World
1981 Casey Powell
- I Think I'm Having A Baby
1981 Laurie Mcintyre
- Angel City
1980 Kristy Teeter
- The Young Runaways
1978 Heather
- The Spy Who Never Was
1976 Girl Playing with Ball (uncredited)
