Margo Martindale
- The Long Haul
2026
- The Twits
2025 Credenza Twit (voice)
- Cocaine Bear
2023 Ranger Liz
- Family Squares
2022 Diane
- Uncle Frank
2020 Mammaw
- Lazy Susan
2020 Mary
- The Kitchen
2019 Helen O'Carroll
- Blow the Man Down
2019 Enid Nora Devlin
- Instant Family
2018 Sandy Wagner
- Downsizing
2017 Woman on Shuttle
- Table 19
2017 Freda Eckberg
- Cars 3
2017 Louise Nash (voice)
- Wilson
2017 Alta
- The Hollars
2016 Sally Hollar
- My Entire High School Sinking Into the Sea
2016 Mrs. Brinson (voice)
- Sophie and the Rising Sun
2016 Anne Morrison
- Mother's Day
2016 Flo
- The Boss
2016 Sister Aluminata
- Bluebird
2014 Crystal
- Heaven Is for Real
2014 Nancy Rawling
- Beautiful Creatures
2013 Delphine Duchannes
- August: Osage County
2013 Mattie Fae Aiken
- Scalene
2011 Janice Trimble
- Win Win
2011 Eleanor
- Secretariat
2010 Miss Ham
- Main Street
2010 Myrtle Parker
- Forged
2010 Dianne
- Orphan
2009 Dr. Browning
- The Winning Season
2009 Donna
- La Soga
2009 Flannigan
- Hannah Montana: The Movie
2009 Ruby
- Management
2009 Trish
- Stop-Loss
2008 Senator's Secretary (voice)
- Mo
2007 Pam
- Walk Hard: The Dewey Cox Story
2007 Ma Cox
- Rocket Science
2007 Coach Lumbly
- Superheroes
2007 Ben's Mother
- Feast of Love
2007 Mrs. Maggarolian
- The Death and Life of Bobby Z
2007 Macy
- The Savages
2007 Roz
- Rails & Ties
2007 Judy Neasy
- Paris Je T'aime
2006 Carol (14ème arrondissement)
- Wedding Daze
2006 Betsy
- Out There
2006 Jen
- 14e Arrondissement
2006 Carol
- Silver Bells
2005 Mrs. Quinn
- Million Dollar Baby
2004 Earline Fitzgerald
- Iron Jawed Angels
2004 Harriot Blatch
- The Best Thief in the World
2004 Miss Mason
- Plainsong
2004 Mrs. Beckman
- The Human Stain
2003 Psychologist
- It's All About Love
2003 Betsy
- An Unexpected Love
2003 Maggie
- The Laramie Project
2002 Trish Steger
- The Hours
2002 Mrs. Latch
- What Girls Learn
2001 Lainey
- 28 Days
2000 Betty
- Proof of Life
2000 Ivy
- Earthly Possessions
1999 Libby
- In Dreams
1999 Nurse Floyd
- Ride with the Devil
1999 Wilma Brown
- Twilight
1998 Gloria Lamar
- Practical Magic
1998 Linda Bennett
- Critical Care
1997 Constance 'Connie' Potter
- ...First Do No Harm
1997 Marjean
- Eye of God
1997 Dorothy
- Marvin's Room
1996 Charlotte Samit
- Ghosts of Mississippi
1996 Clara Mayfield
- Dead Man Walking
1995 Sister Colleen
- Sabrina
1995 Nurse
- Nobody's Fool
1994 Birdy
- The Firm
1993 Nina Huff
- Emma and Elvis
1992 Jenny
- Lorenzo's Oil
1992 Wendy Gimble
- Golden Years
1991 Thelma
- The Rocketeer
1991 Millie
- Days of Thunder
1990 Donna
- The Child Saver
1988 Alma
- Once Again
1987 Debbie Lupino
- Sonny Lovejoy
Gigi
