Melissa McCarthy
- Margie Claus
2027 Producer
- The Murder of JonBenét Ramsey
2026 Executive Producer
- Unfrosted
2024 Donna Stankowski
- Genie
2023 Executive Producer
- The Little Mermaid
2023 Ursula
- Relighting Candles: The Timothy Sullivan Story
2023 Executive Producer
- Thor: Love and Thunder
2022 Actor Hela
- God's Favorite Idiot
2022 Executive Producer
- The Starling
2021 Lilly Maynard
- Thunder Force
2021 Producer
- Nine Perfect Strangers
2021 Executive Producer
- Only Murders in the Building
2021 Doreen
- Bob Ross: Happy Accidents, Betrayal & Greed
2021 Producer
- Superintelligence
2020 Producer
- The Kitchen
2019 Kathy Brennan
- Life of the Party
2018 Writer
- Can You Ever Forgive Me?
2018 Lee Israel
- The Happytime Murders
2018 Producer
- The Box
2018 Director
- Cook-Off!
2017 Amber Strang
- Nobodies
2017 Melissa McCarthy
- The Boss
2016 Screenplay
- Ghostbusters
2016 Abby Yates
- Central Intelligence
2016 Darla (uncredited)
- Gilmore Girls: A Year in the Life
2016 Sookie St. James
- Spy
2015 Susan Cooper
- Tammy
2014 Writer
- St. Vincent
2014 Maggie Bronstein
- Identity Thief
2013 Diana
- The Hangover Part III
2013 Cassie
- The Heat
2013 Mullins
- This Is 40
2012 Catherine
- Bridesmaids
2011 Megan
- The Back-Up Plan
2010 Carol
- Life As We Know It
2010 DeeDee
- Love and Distrust
2010 Tonnie (segment "Auto Motives")
- Mike & Molly
2010 Director
- Pretty Ugly People
2008 Becky
- Just Add Water
2008 Selma
- The Penguins of Madagascar
2008 Shelly (voice)
- The Nines
2007 Margaret / Melissa / Mary
- Samantha Who?
2007 Dena
- Private Practice
2007 Lynn McDonald
- Kim Possible Movie: So the Drama
2005 Amy Hall (voice)
- The Life of David Gale
2003 Nico the Goth Girl
- Charlie's Angels: Full Throttle
2003 Bystander (uncredited)
- Chicken Party
2003 Tot Wagner
- Pumpkin
2002 Cici Pinkus
- The Third Wheel
2002 Marilyn
- White Oleander
2002 Paramedic
- Kim Possible
2002 DNAmy (voice)
- Charlie's Angels
2000 Doris
- Drowning Mona
2000 Shirley
- The Kid
2000 Sky King Waitress
- Auto Motives
2000 Tonnie
- Gilmore Girls
2000 Sookie St. James
- D.C.
2000
- Curb Your Enthusiasm
2000 Saleswoman
- Go
1999 Sandra
- God
1998 Margaret
- The Simpsons
1989 Calvin (voice)
- Untitled Stanley Cup Project
Screenplay
- Miss Nelson Is Missing
Producer
