Parker Posey
- Wild Horse Nine
2026 Marge
- The Mob
2026 Executive Producer
- The Parenting
2025 Brenda
- Thelma
2024 Gail
- Mr. & Mrs. Smith
2024 Other Jane
- Christmas Eve in Miller's Point
2024 Thanks
- Beau Is Afraid
2023 Elaine Bray
- Marvel's Moon Girl and Devil Dinosaur
2023 Kat Swan (voice)
- The Staircase
2022 Freda Black
- Tales of the Walking Dead
2022 Blair Crawford
- The White Lotus
2021 Victoria Ratliff
- Elsewhere
2020 Marie
- The Booksellers
2020 Executive Producer
- High Fidelity
2020 Noreen Parker
- The Con Is On
2018 Gina
- Lost in Space
2018 June Harris / Dr. Zoe Smith
- Columbus
2017 Eleanor
- Palacetor
2016 The Magician
- Café Society
2016 Rad Taylor
- Mascots
2016 Cindi Babineaux
- The Architect
2016 Drew
- My Art
2016 Angie
- Search Party
2016 Brick
- Irrational Man
2015 Rita
- Ned Rifle
2015 Fay Grim
- Grace of Monaco
2014 Madge
- And Now a Word from Our Sponsor
2013 Karen Hillridge
- Highland Park
2013 Shirley Paine
- Hairbrained
2013 Sheila Pettifog
- Drunk History
2013 Mary Phelps Jacob
- Price Check
2012 Susan Felders
- Hemingway & Gellhorn
2012 Mary Welsh Hemingway
- Inside Out
2011 Claire Small
- The Love Guide
2011 Angelica Lovecraft
- Grab
2011 Narrator
- New Girl
2011 Casey
- Portlandia
2011 Branding Expert
- Louie
2010 Liz
- Happy Tears
2009 Jane
- Spring Breakdown
2009 Becky St. Germaine
- Parks and Recreation
2009 Lindsay Carlisle Shay
- Bored to Death
2009 Michelle Whiting
- The Good Wife
2009 Vanessa Gold
- The Eye
2008 Helen Wells
- The Return of Jezebel James
2008 Sarah Tompkins
- Fay Grim
2007 Fay Grim
- Broken English
2007 Nora Wilder
- Superman Returns
2006 Kitty Kowalski
- The Oh in Ohio
2006 Priscilla Chase
- For Your Consideration
2006 Callie Webb
- Adam & Steve
2005 Rhonda
- Frankenstein
2004 Detective Carson O'Conner
- Laws of Attraction
2004 Serena
- Blade: Trinity
2004 Danica Talos
- Boston Legal
2004 Marlene Stanger
- A Mighty Wind
2003 Sissy Knox
- The Event
2003 Nick Devivo
- The Sweetest Thing
2002 Judy Webb
- Personal Velocity
2002 Greta Herskowitz
- Hell on Heels: The Battle of Mary Kay
2002 Jinger Heath
- The Anniversary Party
2001 Judy Adams
- Josie and the Pussycats
2001 Fiona
- Further Tales of the City
2001 Connie Bradshaw Fetzner
- Scream 3
2000 Jennifer Jolie
- Best in Show
2000 Meg Swan
- The Venice Project
1999 Myra
- Futurama
1999 Umbriel (voice)
- You've Got Mail
1998 Patricia Eden
- Henry Fool
1998 Fay Grim
- The Misadventures of Margaret
1998 Margaret Nathan
- What Rats Won't Do
1998 Mirella Burton
- Will & Grace
1998 Dorleen
- More Tales of the City
1998 Connie Bradshaw
- The House of Yes
1997 Jackie-O
- SubUrbia
1997 Erica
- Waiting for Guffman
1997 Libby Mae Brown
- The Daytrippers
1997 Jo Malone
- Clockwatchers
1997 Margaret J. Burrell
- Drunks
1997 Debbie
- Dinner at Fred's
1997 Celia
- Basquiat
1996 Mary Boone
- Frisk
1996 Ferguson
- Flirt
1996 Emily
- The Doom Generation
1995 Brandi
- Kicking and Screaming
1995 Miami
- Party Girl
1995 Mary
- Mixed Nuts
1994 Rollerblader
- Sleep with Me
1994 Athena
- Opera No. 1
1994 Fairy #1
- Dead Connection
1994 Denise
- Iris
1994
- Amateur
1994 Girl Squatter
- Flirt
1993 Emily
- Coneheads
1993 Stephanie
- Dazed and Confused
1993 Darla
- Joey Breaker
1993 Irena Kildare
- Description of a Struggle
1993 Wanda
- Tales of the City
1993 Connie Bradshaw
- Laws of Gravity
1992 Thanks
- The Simpsons
1989 Becky (voice)
- American Playhouse
1982 Connie Bradshaw
