Patricia Clarkson
- The Comebacker
2027
- Lilly
2025 Lilly Ledbetter
- Ransom Canyon
2025 Claire O'Grady
- Monica
2023 Eugenia
- Gray
2023 Cornelia Gray
- She Said
2022 Rebecca Corbett
- Hemingway
2021 Pauline Pfeiffer (voice)
- The Vote
2020
- Out of Blue
2019 Det. Mike Hoolihan
- Almost Love
2019 Ravella Brewer
- State of the Union
2019 Ellen
- Green Eggs and Ham
2019 Pam-I-Am (voice)
- Delirium
2018 Brody
- Jonathan
2018 Dr. Mina Nariman
- Maze Runner: The Death Cure
2018 Ava Paige
- Sharp Objects
2018 Adora Crellin
- The Party
2017 April
- The Bookshop
2017 Violet Gamart
- Super Hummingbirds
2016 Narrator
- Maze Runner: The Scorch Trials
2015 Ava Paige
- Regarding Susan Sontag
2014 Susan Sontag (voice)
- The Maze Runner
2014 Ava Paige
- Learning to Drive
2014 Wendy
- Last Weekend
2014 Celia Green
- October Gale
2014 Helen Matthews
- Annie
2014 Focus Group Woman
- Broad City
2014 Timothy's mother
- The East
2013 Sharon
- House of Cards
2013 Jane Davis
- It's Getting Late
2012 Lou
- The Dust Bowl
2012 Hazel Lucas Shaw
- Rise
2011 Maribel Vinson Owen
- One Day
2011 Alison Mayhew
- Friends with Benefits
2011 Lorna
- Five
2011 Mia
- Prohibition
2011 Reader / Carrie Nation (voice)
- Shutter Island
2010 Rachel 2
- Easy A
2010 Rosemary
- Legendary
2010 Sharon
- Main Street
2010 Willa Jenkins
- Cairo Time
2009 Juliette Grant
- 2081
2009 Narrator
- Whatever Works
2009 Marietta
- Beyond All Boundaries
2009 Marguerite Higgins
- Parks and Recreation
2009 Tammy One
- Vicky Cristina Barcelona
2008 Judy Nash
- Blind Date
2008 Janna
- Married Life
2008 Pat Allen
- Elegy
2008 Carolyn
- Phoebe in Wonderland
2008 Miss Dodger
- No Reservations
2007 Paula
- Lars and the Real Girl
2007 Dagmar
- Amazing Planet
2007 Narrator
- All the King's Men
2006 Sadie Burke
- The Woods
2006 Mrs. Traverse
- Good Night, and Good Luck.
2005 Shirley Wershba
- The Dying Gaul
2005 Elaine Tishop
- American Dad!
2005 Meredith Fields (voice)
- Miracle
2004 Patty Brooks
- Dogville
2003 Vera
- The Station Agent
2003 Olivia Harris
- Pieces of April
2003 Joy Burns
- All the Real Girls
2003 Elvira
- Far from Heaven
2002 Eleanor Fine
- Carrie
2002 Margaret White
- The Safety of Objects
2002 Annette Jennings
- Wendigo
2002 Kim
- The Baroness and the Pig
2002 The Baroness
- Heartbreak Hospital
2002 Lottie Ohrwasher
- Welcome to Collinwood
2002 Rosalind
- The Pledge
2001 Margaret Larsen
- Falling Like This
2001 Caroline Lockhart
- Six Feet Under
2001 Sarah O'Connor
- Joe Gould's Secret
2000 Vivian Marquie
- Wonderland
2000 Tammy Banger
- The Green Mile
1999 Melinda Moores
- Simply Irresistible
1999 Lois McNally
- Wayward Son
1999 Wesley
- Playing by Heart
1998 Allison
- High Art
1998 Greta
- London Suite
1996 Diana Nichols
- Jumanji
1995 Carol Parrish
- Pharaoh's Army
1995 Sarah Anders
- Murder One
1995 Annie Hoffman
- She Led Two Lives
1994 Desiree Parnell
- Caught in the Act
1993 Meg
- Alex Haley's Queen
1993 Lizzie
- Frasier
1993 Claire French
- An American Story
1992 Barbara Meade
- Four Eyes and Six-Guns
1992 Lucy Laughton
- Legacy of Lies
1992 Pat Rafael
- Blind Man's Bluff
1992 Dr. Virginia Hertz
- Davis Rules
1991 Cosmo Yeargin
- The Old Man and the Sea
1990 Mary Pruitt
- Tune in Tomorrow...
1990 Aunt Olga
- Law & Order
1990 Laura Winthrop
- Tales from the Crypt
1989 Suzy
- The Dead Pool
1988 Samantha Walker
- Everybody's All-American
1988 Leslie Stone
- Rocket Gibraltar
1988 Rose Black
- The Untouchables
1987 Catherine Ness
- The Equalizer
1985 Deborah Wade
- Nature
1982 Narrator (voice)
- Saturday Night Live
1975 Mother #2 (uncredited)
- Light on Broken Glass
Melody Harper
- What Happens at Night
Livia Pinheiro-Rima
- A Confederacy of Thelma
Thelma Toole
