Patti LuPone
- Beau Is Afraid
2023 Mona Wassermann
- The School for Good and Evil
2022 Mrs. Deauville
- Show of Titles
2021 "Anything Goes" Performer
- Patti LuPone: Live From the West Side
2020 Herself
- Cliffs of Freedom
2019 Yia-Yia
- Steven Universe: The Movie
2019 Yellow Diamond (voice)
- Last Christmas
2019 Joyce
- Steven Universe: Heart of the Crystal Gems
2018 Yellow Diamond
- The Comedian
2016 Florence Berkowitz
- Dinner with Family with Brett Gelman and Brett Gelman's Family
2015 Patti LuPone
- Parker
2013 Ascension
- Union Square
2011 Lucia
- Company
2011 Joanne
- Rise and Fall of the City of Mahagonny
2007 Leocadia Begbick
- Passion
2005 Fosca
- Candide
2005 The Old Lady
- Broadway's Lost Treasures II
2004 Reno Sweeney (segment "Anything Goes")
- Broadway's Lost Treasures
2003 Eva Perón (segment "Evita")
- City by the Sea
2002 Maggie
- Monday Night Mayhem
2002 Emmy Cosell
- A Little Night Music: Ravinia Festival Concert
2002 Desiree Armfeldt
- Heist
2001 Betty Croft
- Sweeney Todd: The Demon Barber of Fleet Street in Concert
2001 Nellie Lovett
- The Victim
2001 Sandy
- State and Main
2000 Sherry Bailey
- Cold Blooded
2000 Van Klerk
- Just Looking
1999 Sylvia Levine Polinsky
- The 24 Hour Woman
1999 Joan Marshall
- Bonanno: A Godfather's Story
1999 Miss C. Canzinarra
- Summer of Sam
1999 Helen
- An Evening with Patti LuPone
1997 Herself
- Her Last Chance
1996 Joanna Saxen
- The Song Spinner
1995 Zantalalia
- Family Prayers
1993 Aunt Nan
- The Water Engine
1992 Rita Lang
- Sunset Boulevard: Live at the Sydmonton Festival
1992 Norma Desmond
- Driving Miss Daisy
1989 Florine Werthan
- LBJ: The Early Years
1987 Claudia Alta 'Lady Bird' Taylor Johnson
- Wise Guys
1986 Wanda Valentini
- Witness
1985 Elaine
- The Cradle Will Rock
1985 Moll / Mr. Mister’s Daughter
- Love Cycle: A Soap Operetta
1984 Rachel Burston
- Fighting Back
1982 Lisa D'Angelo
- 1941
1979 Lydia Hedberg
- King of the Gypsies
1978 (uncredited)
- The Time of Your Life
1976 Kitty Duval
