- Too Much
2025 Dottie
- Mid-Century Modern
2025 Judy
- The Studio
2025 Matt's Mom (voice)
- You People
2023 Bubby
- Barbie
2023 Ruth
- Not Dead Yet
2023 Janice
- Curses!
2023 Margie (voice)
- Poker Face
2023 Beatrix Hasp (voice)
- 13: The Musical
2022 Grandma Ruth
- Marvelous and the Black Hole
2022 Margot
- Funny Face
2021 Fernie
- Star Wars: The Bad Batch
2021 Cid (voice)
- Mr. Bungle: The Night They Came Home
2020 Spooky Narration
- Poms
2019 Alice
- Saving Flora
2019 Gabriella
- Harley Quinn
2019 Golda (voice)
- The Matchmaker
2018 Irene
- Lemon
2017 Esther
- Me and My Grandma
2017 Grandma
- Sing
2016 Judith (voice)
- Shooter
2016 Supreme Court Justice Gibson
- I'll See You in My Dreams
2015 Sally
- Tim and Eric's Bedtime Stories
2014 Maureen
- Mom
2013 Anya
- Brooklyn Nine-Nine
2013 Estelle
- Kirstie
2013 Thelma Katz
- The Goldbergs
2013 Margot Letien
- Getting On
2013 Crystal Buff
- The Sessions
2012 Mikvah Lady
- The Mindy Project
2012 Annette Castellano
- Robot and Monster
2012 Nessie (voice)
- The Trouble with Bliss
2011 Maria (uncredited)
- Oliver's Ghost
2011 Eloise
- Wilfred
2011 Mittens
- Hot in Cleveland
2010 Jacki
- The Nightman Cometh: Live
2009 Gladys
- Hung
2009
- Beethoven's Big Break
2008 Patricia
- The Christmas Choir
2008 Sister Agatha
- Love Comes Lately
2007 Reisel
- 10 Items or Less
2006 Mrs. D
- Crumbs
2006 Camille Spadaro
- Bye Bye Benjamin
2006 Executive Producer
- Fat Actress
2005 Rhea Perlman
- It's Always Sunny in Philadelphia
2005 Bertha Fussy
- American Dad!
2005 Old Stripper (voice)
- Kevin Hill
2004 Eleanor Frank
- What's New, Scooby-Doo?
2002 Agnes (voice)
- Kate Brasher
2001 Abbie Schaeffer
- How to Marry a Billionaire: A Christmas Tale
2000 Jacqueline Kennedy
- Painful Secrets
2000 Dr. Parella
- A Tale of Two Bunnies
2000 Thelma
- H.E. Double Hockey Sticks
1999 Ms. Beelzebub
- Law & Order: Special Victims Unit
1999 Roxana Fox
- In the Doghouse
1998 Phil Markowitz
- Houdini
1998 Esther
- Monty Python: Live at Aspen
1998 Audience Member (uncredited)
- Becker
1998 Dr. Katherine Simmons
- Ally McBeal
1997 Dr. Helen Tooth
- Union Square
1997 Eileen Mulrooney
- Matilda
1996 Mrs. Wormwood
- Carpool
1996 Martha
- Sunset Park
1996 Phyllis Saroka
- Pearl
1996 Pearl Caraldo
- Canadian Bacon
1995 Deputy Honey
- Almost Perfect
1995
- Spoils of War
1994 Emma
- Sesame Street | All-Star 25th Birthday: Stars and Street Forever!
1994 Worm TV Host
- The Critic
1994 Ardeth (voice)
- A Place to Be Loved
1993 Jerry Blair
- We're Back! A Dinosaur's Story
1993 Mother Bird (voice)
- Frasier
1993 Carla Tortelli
- Class Act
1992 Miss Simpson
- To Grandmother's House We Go
1992 Shirley
- There Goes the Neighborhood
1992 Lydia Nunn
- Mad About You
1992 Mrs. Ramona DiChristophoro
- Shelley Duvall's Bedtime Stories
1992 Narrator (voice)
- Ted & Venus
1991 Grace
- The Last Halloween
1991 Mrs. Gizborne
- Roc
1991
- Amazing Stories: The Movie II
1990 Lois
- The Earth Day Special
1990 Paula
- Enid Is Sleeping
1990 Mavis
- Disneyland's 35th Anniversary Celebration
1990 Carla Tortelli
- Blossom
1990 The Godfather
- Two Daddies?
1989 Rose Johnson (voice)
- The Simpsons
1989 Carla Tortelli (voice)
- A Family Again
1988 Aunt Dee
- Mickey's 60th Birthday
1988 Carla Tortelli
- Stamp of a Killer
1987 Claudia
- Funny, You Don't Look 200: A Constitutional Vaudeville
1987 Maisy - Constitutional Caterer
- The Tortellis
1987 Carla Tortelli
- My Little Pony: The Movie
1986 Reeka (voice)
- My Little Pony
1986
- Matlock
1986 Rhea Perlman
- Happily Ever After
1985 Rose Johnson (voice)
- Amazing Stories
1985 Lois
- The Ratings Game
1984 Francine Kester
- Love Child
1982 June Burns
- Drop-Out Father
1982 Tawney Shapiro
- National Lampoon's Movie Madness
1982 Little Jewish Prostitute ("Municipalians")
- St. Elsewhere
1982 Carla Tortelli
- Cheers
1982 Carla Tortelli
- Swap Meet
1979 Mother
- Like Normal People
1979 Jan
- Taxi
1978 Zena Sherman
- Mary Jane Harper Cried Last Night
1977 Judy
- Intimate Strangers
1977 Barbara
- I Want to Keep My Baby!
1976 Rae Finer
- The Selling of Vince D'Angelo
1976 Vince's Wife
- Stalk the Wild Child
1976 Jean
- Minestrone
1975 Writer
- The Sound Sleeper
1973 Production Coordinator
- Hot Dogs for Gauguin
1972 Woman on Ferry
- The Wonderful World of Disney
1954 Carla Tortelli LeBec
