Sigourney Weaver
- Avatar 5
2031 Kiri
- Avatar 4
2029 Kiri
- The Mandalorian and Grogu
2026 Colonel Ward
- The Gorge
2025 Bartholomew
- Dust Bunny
2025 Laverne
- Avatar: Fire and Ash
2025 Kiri
- Master Gardener
2023 Norma Haverhill
- Avatar: The Way of Water
2022 Kiri
- Call Jane
2022 Virginia
- Oats Studios: Volume 1
2021 Jasper
- Ghostbusters: Afterlife
2021 Dana Barrett
- The Good House
2021 Hildy Good
- My Salinger Year
2020 Margaret
- Protecting the Amazon Demands Radical Change
2020 Narrator
- Off in the Far Away Somewhere: Georgia O’Keeffe’s Hawaii
2018 Georgia O’Keeffe
- Rakka
2017 Jasper
- The Meyerowitz Stories (New and Selected)
2017 Sigourney Weaver
- A Monster Calls
2016 Grandma
- The Assignment
2016 Dr. Rachel Kay
- Ghostbusters
2016 Rebecca Gorin
- Finding Dory
2016 Sigourney Weaver (voice)
- Asteroid: Mission Extreme
2016 Narrator
- Chappie
2015 Michelle Bradley
- Exodus: Gods and Kings
2014 Tuja
- My Depression (The Up and Down and Up of It)
2014 Elizabeth Swados (voice)
- All You Need Is Love
2014 Narrator
- The Cabin in the Woods
2012 The Director
- Vamps
2012 Cisserus
- Red Lights
2012 Margaret Matheson
- Final Cut: Ladies and Gentlemen
2012 (archive footage)
- The Cold Light of Day
2012 Jean Carrack
- Vanya and Sonia and Masha and Spike
2012 Masha
- Paul
2011 The Big Guy
- Cedar Rapids
2011 Macy Vanderhei
- Rampart
2011 Joan Confrey
- Abduction
2011 Dr. Geraldine 'Geri' Bennett
- Tipping Point: The End of Oil
2011 Narrator (voice)
- Crazy on the Outside
2010 Viki
- You Again
2010 Ramona
- Prayers for Bobby
2009 Mary Griffith
- Avatar
2009 Dr. Grace Augustine
- Cinema's Exiles: From Hitler to Hollywood
2009 Narrator (voice)
- The Tale of Despereaux
2008 The Narrator (voice)
- Be Kind Rewind
2008 Ms. Lawson
- Vantage Point
2008 Rex Brooks
- Baby Mama
2008 Chaffee Bicknell
- WALL·E
2008 Ship's Computer (voice)
- Fragile Planet
2008 Narrator
- Happily N'Ever After
2007 Frieda (voice)
- The Girl in the Park
2007 Julia Sandburg
- The TV Set
2007 Lenny
- DNA: Secret of Photo 51
2007 Narrator
- Snow Cake
2006 Linda
- Infamous
2006 Babe Paley
- The Village
2004 Alice Hunt
- Imaginary Heroes
2004 Sandy Travis
- Holes
2003 Warden
- National Geographic : Search for the Afghan Girl
2003 Narrator
- Tadpole
2002 Eve Grubman
- The Guys
2002 Joan
- The Lost Film of Dian Fossey
2002 Narrator (voice)
- Heartbreakers
2001 Max Conners
- Big Bad Love
2001 Betti DeLoreo (voice)
- Through These Eyes
2001 Narrator
- The Roman Empire in the First Century
2001 Narrator
- Company Man
2000 Daisy Quimp
- Galaxy Quest
1999 Gwen DeMarco
- A Map of the World
1999 Alice Goodwin
- Why Dogs Smile and Chimpanzees Cry
1999 Narrator
- Alien Resurrection
1997 Co-Producer
- Snow White: A Tale of Terror
1997 Lady Claudia Hoffman
- The Ice Storm
1997 Janey Carver
- Copycat
1995 Helen Hudson
- Jeffrey
1995 Debra Moorhouse
- Death and the Maiden
1994 Paulina Escobar
- The Wild Swans
1994 Narrator
- Dave
1993 Ellen Mitchell
- 1492: Conquest of Paradise
1992 Queen Isabella
- Alien³
1992 Co-Producer
- The Snow Queen
1992 Narrator (voice)
- Peachboy
1991 Narrator (voice)
- Ghostbusters II
1989 Dana Barrett
- Gorillas in the Mist
1988 Dian Fossey
- Working Girl
1988 Katharine Parker
- Aliens
1986 Ripley
- Half Moon Street
1986 Dr. Lauren Slaughter
- One Woman or Two
1985 Jessica Fitzgerald
- Ghostbusters
1984 Dana Barrett
- Deal of the Century
1983 Mrs. DeVoto
- The Year of Living Dangerously
1982 Jill Bryant
- Eyewitness
1981 Tony Sokolow
- Alien
1979 Ripley
- The Sorrows of Gin
1979 Marcia Lawton
- O Youth and Beauty!
1979 Marcia Lawton
- Madman
1978 Gale
- Annie Hall
1977 Alvy's Date Outside Theatre
